Parkin regulates the mitochondrial stress response in all cells.
Mitochondria are cellular energy factories, essential to life.
The Parkin protein orchestrates removal of damaged mitochondria through mitophagy. In healthy cells, Parkin-mediated mitophagy removes damaged mitochondria before toxic oxidative stress and harmful immune signaling can occur.
Parkin-Dependent Mitophagy
• Damaged mitochondria recruit active Parkin
• Parkin then ubiquitinates specific proteins
• Ubiquitinated proteins signal synthesis of autophagosome
• Damaged portions of mitochondria are segregated and degraded
Parkin-Dependent Mitophagy Provides:
• Pharmacodynamic readouts
• Functional readout biomarkers
• Clinical endpoints
Absence of Parkin activity leads to loss of dopamine neurons.
Replacing Parkin protein restores normal mitochondrial function and energy balance.
At NysnoBio we have dedicated our careers to studying Parkin. Our founder was the first to publish a high-resolution crystal structure showing critical features of how the Parkin enzyme works.
(Activity cycle of the Parkin enzyme)
Our team will be the first to deliver a Parkin therapeutic to patients.